Therapy-free remission in chronic myeloid leukemia: possible mechanism
نویسندگان
چکیده
منابع مشابه
What is treatment free remission in chronic myeloid leukemia?
Chronic myeloid leukemia (CML) has become a model for molecular targeted therapy [1]. It is characterized by a cytogenetic marker, the Philadelphia (Ph) chromosome and its molecular counterpart the BCRABL1 fusion gene. This leukemia-specific molecular marker encodes a protein tyrosine kinase, BCR-ABL1, which is considered as the driver of the leukemic process. This discovery led to the developm...
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We studied telomere length in 32 CML patients who discontinued imatinib after achieving complete molecular remission and 32 age-sex-matched controls. The relative telomere length (RTL) was determined by q-PCR as the telomere to single copy gene (36B4) ratio normalized to a reference sample (K-562 DNA). Age-corrected RTL (acRTL) was also obtained. The 36-month probability of treatment-free remis...
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Several clinical trials have demonstrated that some patients with chronic myeloid leukemia in chronic phase (CML-CP) who achieve sustained deep molecular responses on tyrosine kinase inhibitor (TKI) therapy can safely suspend therapy and attempt treatment-free remission (TFR). Many TFR studies to date have enrolled imatinib-treated patients; however, the feasibility of TFR following nilotinib o...
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Chronic myeloid leukemia (CML) is a hematological cancer, characterized by a reciprocal chromosomal translocation between chromosomes 9 and 22 [t(9;22)], producing the Bcr-Abl oncogene. Tyrosine kinase inhibitors (TKIs) represent the standard of care for CML patients and exert a dual mode of action: direct oncokinase inhibition and restoration of effector-mediated immune surveillance, which is ...
متن کاملUnusual ophthalmic manifestation in chronic myeloid leukemia: A case report
Background: Chronic myeloid leukemia (CML) is a myeloproliferative hematopoietic malignancy with a heterogeneous proliferation of hematopoietic cells in the bone marrow. The ocular manifestations are rare symptoms of CML. In this case report, a CML patient with retinal hemorrhage is reported as an uncommon symptom. Case presentation: A 35-year-old man was referred due to decreased right eye vi...
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ژورنال
عنوان ژورنال: Expert Review of Hematology
سال: 2018
ISSN: 1747-4086,1747-4094
DOI: 10.1080/17474086.2018.1442213